з ǹ ѡҷԷҤԹԡ ԷԿ ҹʫ ѧӡ÷ͧͧķͧЧѺǴ㹤Ѻüҿѹش ҡѧࡵ ҧҧҴ֧ ¾ ͤ˭ԧҡûǴ ЧѺǴҧçչ¡ Kappa-opioids Ŵշش ҡǡѹѺö¤»Ǵ ҧѧѺ֡ŧա
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ᵡҧͧõͺʹ᷺ͧеçѹͧҵ ֧ͧ㨴 蹡ҡЧѺ纻ǴҹԸա÷ѹҹҹԺ ¤ԴǴͧء »Ǵ ѧʹǭѡͧͧͧ ẺԵѧԹ÷ӹͧ äԴҤᵡҧҧդǢͧµçѺеǴ
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ᵡҧԴѺ㹡չҹ š֡ §ҹ ͺ ҵҹѡʺǴѹҧ¹šѺҡҼ˭ԧ ѡԨԷ¹ҷ쾺 ͷӡ÷ͧ俿 еԴ纻Ǵͺ㹡ЧѺǴ ҡ㹼ҹ ѧա֡
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ä鹾ͧǹҵ 5 աѧҡͷԺ觷Դ ͧᵡҧҧȹѧ繷 ѧ鹡觨ҡѧ ֡ҷͺͧͧ纻Ǵҧ ѧ ͵ ⷹ ѡѪԷ 觻ШٹԨ¨쨷ǹš觨ҷ֧ͧͺ »Ǵ ͧռšзҧҡ͡÷ӧҹ㹤Թԡ
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˹Ҿͧᵡҧͧ纻ǴȪ˭ԧҧ ˭ԧ÷ͺҧö纻Ǵ㹡äʹص ǹ¡çֹ֡ ¡仾ѹᾷҹ (ҧ֧Ѻ ͺ͡) ֧բ¡ҧҧ ֡ҷҧբͧ䡤纻ǴԴȪ˭ԧЪͧ 件֧ͧŷᵡҧѹͧǴբ
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ᵡҧҧȡѺ纻Ǵ֧ʹӡ֡Ҩҹ ˵ءҤ纻Ǵͧͧ֡ ԵջѨ·ԷԾǢͧµҧ ´ 鹰ҹѹء ˹觷ӡ÷ͺ ʺóͧ纻ǴʹյлѨغѹ ǧͺШͧ˭ԧ ǡһǴ ҧ繧ҹҡ¨ԧзҹ
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ѧ 㹪ǧԺҹ ÷ͺҵҧ ѡзӡ÷ͺ㹼ͧҡ˭ԧա¹ŧͧüš÷ͧҡ ҧҹѺзҹҤ (觡) ҧҹҨ駤·Һ (ӡ÷ͺҡѺ˭ԧդ Ҩռŵͷá) ѧ鹡÷ͺ㹼¨֧дǡ˹
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.. 2536 Ѱԡ˹÷ͺҵҧ ͧռѺ÷-ͺ˭ԧ ҡռѺ÷ͧ˭ԧ֧ 52% 仾Ԩóҡѹԧ ǡ羺ҡ÷ͧǡѡ繡÷ͧҷѡҹ ǹ÷ͧ 跴ͺä繡ѹ駪˭ԧ¡Թŵ ᷺ᵡҧ仨ҡ
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Ѻ͵ ⷹ ѡҡóӹ¡áͧآҾʵ ͧѰ (FDA) һԷҾмŢҧ§ҧ ͧդᵡҧѹҧȨԧ ͧ繷еͧʴҡѴਹ
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˭ԧ˵آͧǴҧ ѹ ѡлǴѧ ͻǴҡäͧѺ 繵 㹢з˭ԧѡҴҡûǴ ù ͻǴҡäͧاӴ ͧҡͧ˭ԧᵡҧѹ ѧҡûǴ㹺dzǡѹҨշҵҧѹ ҧԴҡǻѭǡѹ ѭҳ üͧᵡҧѹҧȴ
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繵˹觷Դõͺʹͧᵡҧ Ҿ Ҩзӡ ͺ㹤Թԡͧͧ ʧԴ ç͡俿 ˭ԧͧ ÷ӹͧ С緹纻Ǵ¡ ͡ҡ鹤ǵͤ纻Ǵͧ˭ԧǡѹ褧 觵 ͺʹ觵
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ԧ Է¿Դ ͧࡹ ԺǡѺͧ Ҩਹ˭ԧ ਹ繵ǡеШЪѭҳ纻Ǵҧͧ ѹѧл»ҷѺ֡ҧ Ǵ觢
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ǹù Ȫ¨ŵçѹ ¨з鹻ҷͺʹͧͤ纻Ǵŧ ҡó繪Ѵ㹪ǧ駤 Ͷ֧ǧ ش¢ͧõ駤 дѺ ù о٧з֡ѺǴҧçѺ纻Ǵ㹢Фʹ ˵ؼŷҷ˭ԧʹ ҧ֧纻ǴФʹ
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ǹ繤á ѧࡵͧŢͧȹ ֡ҢͧҾѧҿѹش ˭ԧк֡͡-ǴҡҼ ҡûǴԴ鹹鹡繼ͧҨҡѡʺ ѧ ǹ֧ҹҡѭҳͧѡʺ㹪˭ԧᵡҧѹ зӡ÷ͧਹ˹ٵǼ (rat) ǡ羺Ҥҹͤ纻Ǵ ͧѹŧдѺǡѺ˹ٵ ǡӡ÷ͧù
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ͷѹ˹ٵ ҡդҹҡ ҡҶ¹ŧ ҹͤ纻Ǵ¹仴
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֡֡дѺ оռŵͻҷǢͧ ѺѡʺСë ਹ˭ԧѺ駡ҧô䤹Թ ѹӤѭ㹡- ǹѡʺ ǹö繵Ժ觷ԴǴؾѹͧ |
ա˵ط˭ԧ纻Ǵ¡Ҽ¡ ö㹡þٴ ͡ҡ˭ԧФ ͧ㹢ͧس͡ѧáѹա ѧ鹤纻Ǵ֧ö繤֡˹觻Ǵ ա˹觡Ǵ - Ҵ Էવ Ե 繤á鹾ö㹡ä¡ѹͧͧ 繹 ¾㹪ǧҡûǴͧͺ ѡҡûǴѧͧҡҡ鹴
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ä鹾ͧҴ繻ªҧǪҭͧ纻Ǵ 㹤Թԡ ҨоҼҡûѧ Ǵͧҡ´ (irritable bowel syndrome) ѡҡûǴ (fibromyalgia) Ǵ лǴԧҹ (chronic pelvic pain) Ǵ¡عç㹼˭ԧҡҼա ҡҹ§纻Ǵͧеҧ 鹻ҷ͡ѹöԺ觷Դ ͡ҡ鹡ѧҨйª㹡ѡ ¡ŴҡûǴѹѹ˹ǧáҨзҡûǴ ŧ
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Ի ѡҷԷоҺἹٵԹǪҡԷѷ öͧͧᵡҧкѹԺԷԾŢͧáѺ纻Ǵ ѧࡵеԹ ѡ纻ǴҤʹҡҤ á Դ仵Ѳ 繡աʴ͡ҧҧԴǵ һǴͧʹҡ˹ ǡ繼š÷ͧ˹áʹѺéմ᤻䫫Թ (㹾ԡ) ǷЧѺǴ͡ҡ- ١ ʧ÷ش仴¾ԡѴҧкǹЧѺǴҵ ͡ӡ֡¤Ѵ͡˭ԧ硫ԡѹդ㹡úԡҧ ѹ 1-2 駵ѻ仨֧ѹ 3 ǡ羺紨ѴЧѺǴ١Ѵҧԧ
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ᵡҧҧҾкѹҹ ͧ ⷹ ⨹ ӹ¡áԨ¤纻ǴͧԷӡͧͧѺ纻Ǵ˵صҧ ҵ оաõͺʹͧͧͧ¨ش պdzѡѹ˹觷ᵡҧѹ㹼м˭ԧ ҾҼ˭ԧüŤ纻ǴͧǹǺʹ 蹤ҡ֡ҡ ѧ鹡èѴáѺ纻Ǵ㹼˭ԧèеͧա§ູʹ ûͺ仴¡ŴöŴ纻Ǵ
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§ູʹ㨡պҷ㹼´令зҧѹ ҷ ѧ˹ Դ繼µͧʹ 㹡÷ͧ˹觷Է¹ -ԡ ǹ дѺҹͤ纻Ǵͧ¨٧鹶Ҽӡ÷ ͺ˭ԧ ˹蹷ҹռšѺ˭ԧ㴹ѡ š÷ͧʹͧѺŢͧ ͡ ʹ ǪҭҹûԹѡҤ纻Ǵ Է͵Ź ҾҤªͺҧҴçҺ Ǵ͡ ͡Ѻ件֧ҹҴ
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դҹͤ纻Ǵҡ ԧջªҡѡ ˭ԧѡѡҡ纻µ繹 äء˭ռŷ˭ԧ Ҩ֧ҡк͡س· ҡ 㹻ҡ ǿѹͻǴѹ稧պͿѹС纻Ǵ˭Ͷ֧Ѻ Ѻس ˭ԧѹ Ѻ˭ԧդ ҹҡ ѧ»ҡӺҡʹШ
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͢ͺسŨҡ : آѹ
º§ҡ His pain, her pain, New Scientist 19 January 2002
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