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Ǵᵡҧ


 

                з ͹ ǹ ѡҷԷҤԹԡ ԷԿ ҹʫ ѧӡ÷ͧͧķͧЧѺǴ㹤Ѻüҿѹش ҡѧࡵ
ҧҧҴ֧ ¾ ͤ˭ԧҡûǴ ЧѺǴҧçչ¡ Kappa-opioids Ŵշش ҡǡѹѺö¤»Ǵ ҧѧѺ֡ŧա


                ᵡҧͧõͺʹ᷺ͧеçѹͧҵ ֧ͧ㨴 蹡ҡЧѺ纻ǴҹԸա÷ѹҹҹԺ ¤ԴǴͧء »Ǵ ѧʹǭѡͧͧͧ ẺԵѧԹ÷ӹͧ äԴҤᵡҧҧդǢͧµçѺеǴ


                ᵡҧԴѺ㹡չҹ š֡ §ҹ ͺ࿹ ҵҹѡʺǴѹҧ¹šѺҡҼ˭ԧ ѡԨԷ¹ҷ쾺 ͷӡ÷ͧ俿͹ еԴ纻Ǵͺ࿹㹡ЧѺǴ ҡ੾㹼ҹ ѧա֡


                 ä鹾ͧǹҵ 5 աѧҡͷ͸Ժ觷Դ ͧᵡҧҧȹѧ繷 ѧ鹡觨ҡѧ͹ ֡ҷͺͧͧ纻Ǵҧ ѧ ͵ ͹ⷹ ѡѪԷ 觻ШٹԨ¨쨷ǹš觨ҷ֧ͧͺ࿹ »Ǵ ͧռšзҧҡ͡÷ӧҹ㹤Թԡ


                ˹Ҿͧᵡҧͧ纻ǴȪ˭ԧҧ ˭ԧ÷ͺҧö纻Ǵ㹡äʹص ǹ¡çֹ֡ ¡仾ѹᾷҹ (ҧ֧Ѻ ͺ͡) ֧բ¡ҧҧ ֡ҷҧբͧ䡤纻ǴԴȪ˭ԧЪͧ 件֧ͧŷᵡҧѹͧǴբ


                ᵡҧҧȡѺ纻Ǵ֧ʹӡ֡Ҩҹ ˵ءҤ纻Ǵͧͧ֡ ԵջѨ·ԷԾǢͧµҧ ´ 鹰ҹѹء ˹觷ӡ÷ͺ
ʺóͧ纻ǴʹյлѨغѹ ǧͺШ͹ͧ˭ԧ ǡһǴ ҧ繧ҹҡ¨ԧзҹ


                ѧ 㹪ǧԺҹ ÷ͺҵҧ ѡзӡ÷ͺ㹼ͧҡ˭ԧա¹ŧͧüš÷ͧҡ ҧҹѺзҹҤ (觡) ҧҹҨ駤·Һ (ӡ÷ͺҡѺ˭ԧդ
Ҩռŵͷá) ѧ鹡÷ͺ㹼¨֧дǡ˹


                 .. 2536 Ѱԡ˹÷ͺҵҧ ͧռѺ÷-ͺ˭ԧ ҡռѺ÷ͧ˭ԧ֧ 52% 仾Ԩóҡѹԧ ǡ羺ҡ÷ͧǡѡ繡÷ͧҷѡҹ ǹ÷ͧ 跴ͺä繡ѹ駪˭ԧ¡Թŵ ᷺ᵡҧ仨ҡ


                Ѻ͵ ͹ⷹ ѡҡóӹ¡áͧآҾʵ ͧѰ (FDA) һԷҾмŢҧ§ҧ ͧդᵡҧѹҧȨԧ ͧ繷еͧʴҡѴਹ


                ˭ԧ˵آͧǴҧ ѹ ѡлǴѧ ͻǴҡäͧѺ͹ 繵 㹢з˭ԧѡҴҡûǴ ù ͻǴҡäͧاӴ ͧҡͧ˭ԧᵡҧѹ ѧҡûǴ㹺dzǡѹҨշҵҧѹ ҧԴҡǻѭǡѹ ѭҳ üͧᵡҧѹҧȴ


                繵˹觷Դõͺʹͧᵡҧ Ҿ Ҩзӡ
ͺ㹤Թԡͧͧ ʧԴ͹ ç͡俿 ˭ԧͧ ” ÷ӹͧ С緹纻Ǵ¡ ͡ҡ鹤ǵͤ纻Ǵͧ˭ԧǡѹ褧 觵͹ ͺ͹ʹ觵


                 ԧ Է¿Դ ͧࡹ ͸ԺǡѺͧ Ҩਹ˭ԧ ਹ繵ǡеШЪѭҳ纻Ǵҧͧ ѹѧл»ҷѺ֡ҧ Ǵ觢


                ǹù Ȫ¨ŵçѹ ¨з鹻ҷͺʹͧͤ纻Ǵŧ ҡó繪Ѵ㹪ǧ駤 Ͷ֧ǧ
͹ش¢ͧõ駤 дѺ ù о٧з֡͹ѺǴҧçѺ纻Ǵ㹢Фʹ ˵ؼŷҷ˭ԧʹ
ҧ֧纻ǴФʹ


                ǹ繤á ѧࡵͧŢͧȹ ֡ҢͧҾѧҿѹش ˭ԧк֡͡-ǴҡҼ ҡûǴԴ鹹鹡繼ͧҨҡѡʺ ѧ ǹ֧԰ҹҡѭҳͧѡʺ㹪˭ԧᵡҧѹ зӡ÷ͧਹ˹ٵǼ (rat) ǡ羺Ҥҹͤ纻Ǵ
ͧѹŧдѺǡѺ˹ٵ ǡӡ÷ͧù


               ͷѹ˹ٵ ҡդҹҡ ҡҶ¹ŧ ҹͤ纻Ǵ¹仴


                ֡֡дѺ оռŵͻҷǢͧ
ѺѡʺСë ਹ˭ԧѺ駡ҧô䤹Թ ѹӤѭ㹡- ǹѡʺ ǹö繵͸Ժ觷ԴǴ͹ؾѹͧ


                ա˵ط˭ԧ纻Ǵ¡Ҽ¡ ö㹡þٴ ͡ҡ˭ԧФ ͧ㹢ͧس͡ѧáѹա ѧ鹤纻Ǵ֧ö繤֡˹觻Ǵ ա˹觡Ǵ - Ҵ Էવ Ե 繤á鹾ö㹡ä¡ѹͧͧ 繹 ¾㹪ǧҡûǴͧͺ͹ ѡҡûǴѧͧҡҡ鹴

                ä鹾ͧҴ繻ªҧǪҭͧ纻Ǵ 㹤Թԡ ҨоҼҡûѧ Ǵͧҡ´ (irritable bowel syndrome) ѡҡûǴ (fibromyalgia) Ǵ лǴԧҹ (chronic pelvic
pain) Ǵ¡عç㹼˭ԧҡҼա ҡ԰ҹ§纻Ǵͧеҧ 鹻ҷ͡ѹö͸Ժ觷Դ ͡ҡ鹡ѧҨйª㹡ѡ ¡ŴҡûǴѹѹ˹ǧáҨзҡûǴ ŧ


                  Ի ѡҷԷоҺἹٵԹǪҡԷѷ öͧͧᵡҧк׺ѹ͸ԺԷԾŢͧáѺ纻Ǵ ѧࡵеԹ ໹ѡ纻ǴҤʹҡҤ á Դ仵Ѳ 繡աʴ͡ҧҧԴǵ һǴͧʹҡ˹ ǡ繼š÷ͧ˹áʹѺéմ᤻䫫Թ (㹾ԡ) ǷЧѺǴ͡ҡ- ١ ʧ÷ش仴¾ԡѴҧкǹЧѺǴҵ ͡ӡ֡¤Ѵ͡˭ԧ硫ԡѹդ㹡úԡҧ ѹ 1-2 駵ѻ仨֧ѹ 3 ǡ羺紨ѴЧѺǴ١Ѵҧԧ


                ᵡҧҧҾк׺ѹҹ ͧ
͹ⷹ ⨹ ӹ¡áԨ¤纻ǴͧԷӡ᡹ͧͧѺ纻Ǵ˵صҧ ҵ оաõͺʹͧͧͧ¨ش պdzѡѹ˹觷ᵡҧѹ㹼м˭ԧ ҾҼ˭ԧüŤ纻ǴͧǹǺʹ 蹤ҡ֡ҡ ѧ鹡èѴáѺ纻Ǵ㹼˭ԧèеͧա§ູʹ ûͺ仴¡ŴöŴ纻Ǵ


                §ູʹ㨡պҷ㹼´令зҧѹ ҷ
ѧ˹ Դ繼µͧʹ 㹡÷ͧ˹觷Է¹ -ԡ ǹ дѺҹͤ纻Ǵͧ¨٧鹶Ҽӡ÷
ͺ˭ԧ ˹蹷ҹռšѺ˭ԧ㴹ѡ š÷ͧʹͧѺŢͧ ͡ ʹ ǪҭҹûԹѡҤ纻Ǵ
Է͵Ź ҾҤªͺҧҴ͹çҺ
Ǵ͡ ͡Ѻ件֧ҹҴ


                 դҹͤ纻Ǵҡ ԧջªҡѡ ˭ԧѡѡҡ纻µ繹 ͹äء˭ռŷ˭ԧ׹ Ҩ֧ҡк͡س· ҡ 㹻ҡ ǿѹͻǴѹ稧պͿѹС͹纻Ǵ˭Ͷ֧Ѻ ͹Ѻس
˭ԧ͹ѹ Ѻ˭ԧդ ҹҡ ѧ»ҡӺҡ͹ʹШ






͢ͺسŨҡ
:  آѹ
º§ҡ His pain, her pain, New Scientist 19 January 2002






 












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